Stilbene derivatives from melinjo extract have antioxidant and immune modulatory effects in healthy individuals

Jorge Luis Espinoza; Dao T. T. An; Ly Quoc Trung; Kayoko Yamada; Shinji Nakao; Akiyoshi Takami

Integrative Molecular Medicine · 2015 · Tập 2(6)

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Tóm tắt

The ethanol extract of Melinjo seeds (MSE), an edible fruit native to Southeast Asia, is rich in resveratrol dimer (gnetin C) and other stilbenes.In preclinical studies MES was shown to exert antioxidant, anti-inflammatory and other health promoting activities.This study evaluated the cellular and molecular immune responses in 5 healthy volunteers at baseline and after the oral administration of MSE for 28 days.The administration of MES resulted in a significant increase in the antioxidant activity of the plasma and a decrease in the protein carbonyl content of the plasma compared with the corresponding baseline levels.The circulating numbers of B and T lymphocytes remained essentially unchanged throughout the course of the study, however MES consumption was associated with an increase in the proportion of circulating NK cells and regulatory T cells (CD3+, CD4+, CD25, CD127low/neg).In addition, MES-treated peripheral blood mononuclear cells more efficiently generated Treg cells in vitro compared with their un-treated counterparts.These findings demonstrate that MES modulates oxidative stress parameters in the plasma of healthy individuals and has biological effects on immune cells.

Nguyên văn tóm tắt của bài gốc đăng trên Integrative Molecular Medicine.

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